Shyni Varghese


Professor of Orthopaedic Surgery

Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.

A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:

  • Musculoskeletal tissue repair
  • Disease biophysics, and
  • Organ-on-a-chip technology

A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.

Appointments and Affiliations

  • Professor of Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information:

  • Email Address:
  • Websites:


  • Ph.D. National Chemical Laboratory (India), 2002

In the News:

Representative Publications:

  • Hwang, Y; Seo, T; Hariri, S; Choi, C; Varghese, S, Matrix Topographical Cue-Mediated Myogenic Differentiation of Human Embryonic Stem Cell Derivatives, Polymers, vol 9 no. 11 (2017), pp. 580-580 [10.3390/polym9110580] [abs].
  • Agrawal, G; Aung, A; Varghese, S, Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury., Lab on a Chip, vol 17 no. 20 (2017), pp. 3447-3461 [10.1039/c7lc00512a] [abs].
  • Shih, Y-R; Kang, H; Rao, V; Chiu, Y-J; Kwon, SK; Varghese, S, In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism, Proceedings of the National Academy of Sciences of USA, vol 114 no. 21 (2017), pp. 5419-5424 [10.1073/pnas.1702576114] [abs].
  • Kang, H; Shih, Y-RV; Nakasaki, M; Kabra, H; Varghese, S, Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts., Science Advances, vol 2 no. 8 (2016) [10.1126/sciadv.1600691] [abs].
  • Wen, C; Kang, H; Shih, Y-RV; Hwang, Y; Varghese, S, In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells., Drug Delivery and Translational Research, vol 6 no. 2 (2016), pp. 121-131 [10.1007/s13346-015-0242-2] [abs].