Shyni Varghese


Professor of Orthopaedic Surgery

Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.

A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:

  • Musculoskeletal tissue repair
  • Disease biophysics, and
  • Organ-on-a-chip technology

A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.

Appointments and Affiliations

  • Professor of Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information:

  • Email Address:
  • Websites:


  • Ph.D. National Chemical Laboratory (India), 2002

Courses Taught:

  • BME 791: Graduate Independent Study

In the News:

Representative Publications:

  • González Díaz, EC; Shih, Y-RV; Nakasaki, M; Liu, M; Varghese, S, Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells., Tissue Engineering, Part A, vol 24 no. 13-14 (2018), pp. 1148-1156 [10.1089/ten.tea.2017.0297] [abs].
  • Moreno, AM; Fu, X; Zhu, J; Katrekar, D; Shih, Y-RV; Marlett, J; Cabotaje, J; Tat, J; Naughton, J; Lisowski, L; Varghese, S; Zhang, K; Mali, P, In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation., Molecular Therapy, vol 26 no. 7 (2018), pp. 1818-1827 [10.1016/j.ymthe.2018.04.017] [abs].
  • Seale, N; Ramaswamy, S; Shih, Y-R; Verma, I; Varghese, S, Macroporous dual compartment hydrogels for minimally invasive transplantation of primary human hepatocytes., Transplantation (2018) [10.1097/tp.0000000000002330] [abs].
  • Shih, YV; Varghese, S, Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials., Biomaterials (2018) [10.1016/j.biomaterials.2018.06.005] [abs].
  • Varghese, S, Role of Matrix Proteins in Balancing Tissue Stiffness and Inflammation in Fibrosis, Biophysical Journal, vol 114 no. 3 (2018), pp. 23A-23A [abs].